81-874-Isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile has been used as a starting material.
Reaction of 4-isobutyl-1,6-dihydro-1-methyl-2-(methylthio)-6-oxopyrimidine-5-carbonitrile with hydrazine hydrate and
amine gives 2-hydrazino and 2-(alkyl/ substituted aryl amino)-4-isobutyl-1,6-dihydro-1-methyl-6-oxopyrimidine-5-
carbonitrile compounds respectively. The hydrazino compounds react with different aromatic aldehydes, substituted benzene
sulphonyl chloride and s-triazine derivative to form Schiff base, sulphonamide and s-triazine derivatives respectively.
Reaction of Schiff base with mercapto lactic acid and chloroacetyl chloride yield 4-thiazolidinones and 2-azetidinones
respectively