Acute chest syndrome is a life-threatening complication in sickle cell disease. Infections are frequently implied,
and like other viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be a trigger.
In addition, due to their inflammatory status, they may present a higher risk for severe coronavirus disease 2019 (COVID-19). Pneumonia and acute chest syndrome share clinical, laboratory, and radiological
features and may overlap, which makes their differential diagnosis especially challenging. We describe a case
of an adolescent with homozygous sickle cell disease that developed acute chest syndrome in the context of
COVID-19. With it, we intend to bring awareness to the potential role of imaging in the differential diagnosis
and in establishing the best approach for the patient. Chest computed tomography findings were suggestive
of an alternative diagnosis to COVID-19 pneumonia and red cell transfusion, fluid management, analgesics, and antibiotics were administered with favorable outcome.info:eu-repo/semantics/publishedVersio
