Bas\ue1\uf1ez, Maria-Gloria

Colebunders, Robert

Coulibaly, Michel E.

Coulibaly, Siaka Y.

Coulibaly, Yaya I.

Demb\ue9l\ue9, Massitan

Diallo, Abdallah A.

Diarra, Dansine

Dicko, Ilo

Dolo, Housseini

Doumbia, Salif S.

Nutman, Thomas B.

Sangare, Moussa B.

Soumaoro, Lamine

Sow, Moussa

Walker, Martin

Abstract: Background. Ivermectin-based onchocerciasis elimination, reported in 2009-2012, for Bakoye and Faleme, Mali, supported policy-shifting from morbidity control to elimination of transmission (EOT). These foci are coendemic with lymphatic filariasis (LF). In 2007-2016 mass ivermectin plus albendazole administration was implemented. We report Ov16 (onchocerciasis) and Wb123 (LF) seroprevalence after 24-25 years of treatment to determine if onchocerciasis EOT and LF elimination as a public health problem (EPHP) have been achieved. Methods. The SD Bioline Onchocerciasis/LF Ig[immunoglobulin]G4 biplex rapid diagnostic test (RDT) was used in 2186 children aged 3-10 years in 13 villages (plus 2 hamlets) in Bakoye and in 2270 children in 15 villages (plus 1 hamlet) in Faleme. In Bakoye, all-age serosurveys were conducted in 3 historically hyperendemic villages (1867 individuals aged 3-78 years). Results. In Bakoye, IgG4 seropositivity was 0.27% (95% confidence interval [CI] = .13%-.60%) for both Ov16 and Wb123 antigens. In Faleme, Ov16 and Wb123 seroprevalence was 0.04% (95% CI = .01%-.25%) and 0.09% (95% CI = .02%-.32%), respectively. Ov16-seropositive children were from historically meso/hyperendemic villages. Ov16 positivity was = 40 year-olds. Wb123 seropositivity was = 40 year-olds. Conclusions. Notwithstanding uncertainty in the biplex RUT sensitivity, Ov16 and Wb123 seroprevalence among children in Bakoye and Faleme is consistent with EOT (onchocerciasis) and EPHP (LF) since stopping treatment in 2016. The few Ov16-seropositive children should be skin-snip polymerase chain reaction tested and followed up

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Serological evaluation of onchocerciasis and lymphatic filariasis elimination in the Bakoye and Fal\ue9m\ue9 Foci, Mali

Serological evaluation of onchocerciasis and lymphatic filariasis elimination in the Bakoye and Fal\ue9m\ue9 Foci, Mali

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Institutional Repository Universiteit Antwerpen