Koppen, Carina

N\ued Dhubhghaill, Sorcha

Van den Bogerd, Bert

Van Meenen, Joris

Abstract: The cornea is an important barrier to consider when developing ophthalmic formulations, but proper modelling of this multi-layered tissue remains a challenge. This due to the varying properties associated with each layer in addition to the dynamics of the tear film. Hence, the most representative models to date rely on animals. Animal models, however, differ from humans in several aspects and are subject to ethical limitations. Consequently, in vitro approaches are being developed to address these issues. This review focusses on the barrier properties of the cornea and evaluates the most advanced 3D cultures of human corneal equivalents in literature. Their application potential is subsequently assessed and discussed in the context of preclinical testing along with our perspective towards the future

An overview of advanced in vitro corneal models : implications for pharmacological testing

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