Acurcio, Leonardo Borges

Bastos, Rafael Wesley

Cassali, Geovanni Dantas

de Cicco Sandes, Savio Henrique

de Souza, Marcelo Resende

dos Reis, Diego Carlos

Lebeer, Sarah

Nicoli, Jacques Robert

Sant'anna, Felipe Machado

Sousa Pietra Pedroso, Silvia Helena

Vieira, Andrea Faria

Wuyts, Sander

Abstract: Probiotics form a promising strategy to maintain intestinal health. Milks fermented with probiotic strains, such as the Lactobacillus paracasei ST11, are largely commercialized in Brazil and form a low-cost alternative to probiotic pharmaceutical formulations. In this study, we assessed the probiotic effects of milk fermented by L. paracasei ST11 (administered through fermented milk) in a Salmonella typhimurium infection model in BALB/c mice. We observed in this murine model that the applied probiotic conferred protective effects against S. typhimurium infection, since its administration reduced mortality, weight loss, translocation to target organs (liver and spleen) and ileum injury. Moreover, a reduction in the mRNA expression of pro-inflammatory cytokines such as IFN-gamma, IL-6, TNF-alpha and IL-17 in animals that received the probiotic before challenge was observed. Additionally, the ileum microbiota was better preserved in these animals. The present study highlights a multifactorial protective aspect of this commercial probiotic strain against a common gastrointestinal pathogen

Institutional Repository Universiteit Antwerpen

Milk fermented by Lactobacillus paracasei NCC 2461 (ST11) modulates the immune response and microbiota to exert its protective effects against Salmonella typhimurium infection in mice

Milk fermented by Lactobacillus paracasei NCC 2461 (ST11) modulates the immune response and microbiota to exert its protective effects against Salmonella typhimurium infection in mice

Abstract

Similar works

Full text

Available Versions

Institutional Repository Universiteit Antwerpen