Coeffic, David

Garcia, Yolanda

Gebski, Val

Gibbs, Emma

Gonzalez-Martin, Antonio

Hilpert, Felix

Huizing, Manon

Kaern, Janne

Kristensen, Gunnar

Lee, Chee Khoon

Levache, Charles-Briac

Luck, Hans-Joachim

Pujade-Lauraine, Eric

Roemer-Becuwe, Celia

Sorio, Roberto

Witteveen, Petronella

Zagouri, Flora

Abstract: Background. The AURELIA trial demonstrated significantly improved progression-free survival (PPS) with bevacizumab added to chemotherapy for platinum-resistant ovarian cancer (PROC). Methods. Patients with PROC were randomised to receive investigator-selected single-agent chemotherapy alone or with bevacizumab. Post-hoc exploratory analyses assessed efficacy, safety and patient-reported outcomes according to age = 65 years, baseline hypertension was more frequent and ascites was less common than in patients = 65 versus = 3 hypertension was more common with bevacizumab than chemotherapy alone in both subgroups, and more common in older than younger patients irrespective of treatment. However, there was no excess of other adverse events of specific interest for bevacizumab, including venous thromboembolic events, in older patients. More patients receiving bevacizumab in the younger but not the older subgroup showed improved gastrointestinal/abdominal symptoms. Conclusion. In exploratory analyses, PFS and response rate improvement with bevacizumab were consistent in older and younger patients. Grade >= 3 hypertension was more common in elderly bevacizumab-treated patients; careful monitoring is recommended. Overall, bevacizumab-containing therapy was well tolerated in a selected population aged >= 65 years, suggesting a favourable benefit:risk profile. However, geriatric assessments are needed to improve selection of elderly patients potentially gaining symptom and quality of life improvements from bevacizumab-containing therapy. (C) 2016 Elsevier Inc. All rights reserved

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Safety and efficacy of single-agent bevacizumab-containing therapy in elderly patients with platinum-resistant recurrent ovarian cancer: Subgroup analysis of the randomised phase III AURELIA trial

Safety and efficacy of single-agent bevacizumab-containing therapy in elderly patients with platinum-resistant recurrent ovarian cancer: Subgroup analysis of the randomised phase III AURELIA trial

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Institutional Repository Universiteit Antwerpen