Abstract: Increased demand for building infrastructure delivery advocates for innovative construction methods. This paper examines the concept and application of Modern Method of Construction used in the South-West UK, and the Innovative Building Technologies in South Africa. It assesses the methods, current use, off-site manufacturing; identifies and evaluates aspects of the construction process typically used with the aim of identifying and analysing the barriers and merits for the adoption in the Ghanaian construction industry. The research design adopts a qualitative method and case study of two housing projects as part of a broader study to determine an appropriate innovative construction method to meet project targets of time, cost, quality and improved delivery for the Ghanaian industry. The study finds; convenience; speed; reduced cost and improved delivery as the key success factors though there is less than 5% use of the innovative methods in the entire sector for mainly repetitive housing, schools and hospital projects. Negative end-users perception of building quality and low satisfaction; less government intervention through education; promotion; availability of off-site contractors and materials were also the barriers identified. Management contract is adopted in most cases hence the risk transferred to the management contractors. Lessons learnt are outlined and recommendation made for government action plans to mitigate the barriers during its implementation in the Ghanaian construction industry