Adiponectin gene variant +276G>T independently predicts incident coronary heart disease in men: a 16-year prospective studypublished_or_final_versio

Cheung, BMY

Cheung, YY

Fong, HY

Hui, YLE

Janus, ED

Lam, KSL

Ong, KL

Sham, PC

Tse, HF

Tso, AWK

Wat, NMS

Xu, A

Hong Kong Medical Journal

HKU Scholars Hub

TitleAdiponectin gene variant +276G>T independently predictsincident coronary heart disease in men: a 16-year prospectivestudyAuthor(s)Cheung, YY; Hui, YLE; Cheung, BMY; Tso, AWK; Xu, A; Fong,HY; Ong, KL; Wat, NMS; Janus, ED; Tse, HF; Sham, PC; Lam,KSLCitation19th Medical Research Conference, Department of Medicine, TheUniversity of Hong Kong, Queen Mary Hospital, Hong Kong, 18January 2014. In Hong Kong Medical Journal, 2014, v. 20 n. 1,Suppl. 1, p. 16, abstract no. 16Issued Date 2014URL http://hdl.handle.net/10722/211324Rights Hong Kong Medical Journal. Copyright © Hong Kong Academyof Medicine Press.16 Hong Kong Med J  µ  Volume 20 Number 1 (Supplement 1)  µ  February 2014  µ  www.hkmj.orgVitamin K intake reduces mortality in people with chronic kidney diseaseCL Cheung1,2, S Sahni3, BMY Cheung1, CW Sing2, ICK Wong21 Department of Medicine, The University of Hong Kong, Hong Kong2 Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong3 IFAR, Hebrew SeniorLife, Harvard Medical School, Boston, United StatesBackground: Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD), partly due to increased vascular calciﬁcation. Emerging evidence suggests that vitamin K plays a key role in preventing vascular calciﬁcation in CKD. However, the relationship between vitamin K intake and mortality in people with CKD remains unknown. The objective of this study was to examine the association of vitamin K intake with all-cause and CVD mortality in a nationally representative sample aged 20 years or above.Methods: A total of 3401 participants with CKD from the Third National Health and Nutrition Examination Survey were included. Dietary intake was assessed during nutritional examination based on 24-hour dietary recall. Vitamin K intake was used in multivariate Cox regression analysis to predict all-cause and CVD mortality. Results: During a median follow-up of 13.3 years (37 408 person-years), 1815 and 876 participants died from all-cause and CVD causes, respectively. The majority of participants had vitamin K intake lower than the recommended intake levels. In multivariable Cox-regression analysis, participants in higher quintiles (quintile 4-5) of vitamin K intake had signiﬁcantly lower risk of all-cause (hazard ratio [HR] = 0.86; 95% conﬁdence interval [CI], 0.75-1; P = 0.046) and CVD mortality (HR = 0.79; 95% CI, 0.64-96; P = 0.021) when compared with quintiles 1 through 3. Participants with vitamin K intake higher than recommended adequate intake value for vitamin K were associated with lower risk of all-cause and CVD mortality. Conclusion: These ﬁndings suggest that adequate-to-high level of vitamin K intake reduces CVD and all-cause mortality in people with CKD.15Adiponectin gene variant +276G>T independently predicts incident coronary heart disease in  men: a 16-year prospective study CYY Cheung1, EYL Hui1,2, BMY Cheung1,2, AWK Tso1,2, A Xu1,2, CHY Fong1, KL Ong1, NMS Wat1, ED Janus1, HF Tse1,2, PC Sham3,4, KSL Lam1,2 1 Department of Medicine 2 Research Centre of Heart, Brain, Hormone and Healthy Aging3 Department of Psychiatry4 The Centre for Genomic SciencesLi Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongIntroduction: Adiponectin has been suggested to play a protective role in the development of coronary heart disease (CHD). However, recent prospective studies suggested that high adiponectin levels are associated with a higher risk of cardiovascular mortality in an established CHD cohort. Study of genetic variants of the adiponectin gene (ADIPOQ) may provide more insights into the primary role of adiponectin in CHD development. Our objective was to examine the prospective relationship between the genetic variants of ADIPOQ and incident CHD in a 16-year prospective population-based cohort of southern Chinese.Methods: Nine ADIPOQ genetic variants with potential functional relevance or shown to be associated with adiponectin levels and/or CHD were genotyped in 2196 subjects from the Hong Kong Cardiovascular Risk Factors Prevalence Study (CRISPS), who were free of CHD at baseline. Among these subjects, 184 had developed CHD over the 16-year follow-up period.Results: The ADIPOQ +276G>T variant was found to be independently associated with incident CHD in men but not in women, even after adjustments for different sets of conventional cardiovascular risk factors (Padjusted = 5.5 x 10-3 to 0.023; hazard ratio = 1.39 to 1.54). Moreover, the T allele of +276G>T was found to be signiﬁcantly associated with reduced plasma adiponectin level (P = 0.027) in 1676 subjects with available plasma samples for analysis.Conclusion: This study supports a protective role of adiponectin in the development of CHD in the general population.16

Adiponectin gene variant +276G>T independently predicts incident coronary heart disease in men: a 16-year prospective study

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Adiponectin gene variant +276G>T independently predicts incident coronary heart disease in men: a 16-year prospective study

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