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H5N1 virus causes significant perturbations in host proteome very early in influenza virus-infected primary human monocyte-derived macrophages
Authors
JT Bryan
EY Chan
+8 more
CY Cheung
KPY Hui
MG Katze
A Krasnoselsky
CKL Leung
AT Navare
JSM Peiris
D Purdy
Publication date
1 January 2012
Publisher
'Oxford University Press (OUP)'
Doi
Cite
Abstract
H5N1 influenza viruses, which cause disease in humans, have unusually high pathogenicity. The temporal response of primary human monocyte-derived macrophages infected with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrometry-based quantitative proteomic profiling. This was done in order to demonstrate significant perturbation of the host proteome upon viral infection, as early as 1 hour after infection. This early host response distinguished H5N1 infection from H1N1 infection, the latter inducing less of a response. The most pronounced effect was observed on the translational machinery, suggesting that H5N1 might gain advantage in replication by using the cell protein synthesis machinery early in the infection. © The Author 2012.link_to_subscribed_fulltex
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Last time updated on 01/06/2016