INTRODUCTION :
Globally, traditional medicine is widely used to treat a variety of injuries and illnesses, including dog bites, and exposures that are risky for rabies. However, efficacy of most traditional
remedies used for rabies prevention or treatment has not been demonstrated in controlled
trials or proven in community-based surveys.
METHODS :
Six databases were searched including the terms rabies, traditional treatment, traditional
remedy, traditional therapy, traditional medicine, and medicinal treatment to review traditional remedies used in the prevention and treatment of rabies. In addition, published literature of rabies transmission dynamics was used to estimate statistical likelihood of dog bite
victims developing rabies to provide clarity as to why traditional healers have a high apparent success rate when preventing death from rabies in victims bitten by suspected rabid
dogs.
RESULTS :
Literature review yielded 50 articles, including three controlled experiments, that described
use of traditional remedies for rabies prevention and treatment. Traditional remedies for
rabies ranged from plant- or animal-based products to spiritual rituals; however, only a few
controlled mice trials were conducted, and none of these trials demonstrated efficacy in preventing or treating rabies. Risk of dying from rabies after a bite from a dog with unknown
rabies status is low, 1.90% (0.05%-29.60%). Therefore, traditional healers had a 98.10%
(70.40%-99.95%) apparent success rate in preventing death from suspected rabid dog bites
despite inefficaciousness of herbal remedies. CONCLUSION :
There was no universal plant species or route of administration that was consistently used
for rabies prevention or treatment across countries. No traditional remedy was efficacious in
the prevention or treatment of rabies in randomized controlled experiments. Understanding
the cultural context under which traditional remedies are used may facilitate collaboration of
traditional healers with the modern medical system to ensure timely and appropriate use of
proven therapies for prevention and clinical management of rabies.https://journals.plos.org/plosntdsdm2022BiochemistryGeneticsMicrobiology and Plant Patholog
