Purpose: To introduce optimal experimental design techniques in the cytogenetic
biological dosimetry practice. This includes the development of a new optimatility
criterion for the calibration of radiation doses.
Materials and Methods: The most typical optimal design criterion and the one
developed in this research are introduced and applied in an example from the litera-
ture. In another example from the literature, a simulation study has been performed
to compare the standard error of the dose estimation using di erent experimental
designs. An RStudio project and a GitHub project have been developed to repro-
duce these results.
Results: It is appreciated how the application of optimal experimental design tech-
niques can reduce the standard error of biodosimetric dose estimations.
Conclusions: Optimal experimental design techniques jointly with practitioners re-
quirements may be applied. This practice would not involve an additional laboratory
work
