Abo, Takafumi

Hidaka, Shigekazu

Isomoto, Hajime

Nagayasu, Takeshi

Nakao, Kazuhiko

Nanashima, Atsushi

Norimura, Daisuke

Ohnita, Ken

Onaka, Takashi

Sawai, Terumitsu

Takeshima, Fuminao

Takeshita, Hiroaki

Tobinaga, Syuuichi

Yajima, Hiroyuki

Yamaguchi, Naoyuki

Surgical resection is the only radical treatment option for duodenal ampullar carcinoma (AC) that results in an improved patient prognosis. Method: We examined the demographics, surgical records, and outcome in 23 patients with AC undergoing pancreaticoduodenectomy (PD). Results: Of 23 patients, 17 underwent pylorus preserving PD (PPPD) and 6 underwent PD, including subtotal stomach-preserving PD in 5. D2 lymphadenectomy was performed in 17 patients and D3 lymphadenectomy was performed in 6. The combined resection of the superior mesenteric vein was performed in 1 patient. Postoperative cancer recurrence was observed in 32%, and 6 patients died of cancer. The 3-year tumor-free survival rates were not different between the final stages (p=0.64) and the 5-year cancer-related overall survival rates were not different between stages either (p=0.28). Tumor size?3cm resulted in significantly poorer survival rate compared to smaller tumors (p=0.032). Node metastasis at Group 2, and moderately or poorly differentiated adenocarcinoma were significantly associated with poor survival (p<0.05); however, cancer infiltration at cut-end margin, degree of node dissection and curability were not associated with overall prognosis. Conclusions: Radical surgical resection showed good patient prognosis; however, new adjuvant chemotherapy is a promising modality to improve patient survival in AC patients with poor prognostic factors.Acta Medica Nagasakiensia, 55(1), pp.23-28; 201

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Evaluation of Surgical Resection for Ampullar Carcinoma at Japanese Single Cancer Institute

Evaluation of Surgical Resection for Ampullar Carcinoma at Japanese Single Cancer Institute

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