This research aimed to determine phytochemical content combination between Morinda Citrifolia linn. extract and VCO, getting the best solution for their combining formulation and get the data of antioxidative and hepatoprotective activity in vitro and in vivo, the combination between VCO and Morinda Citrifolia Linn extract. Stages of the research consisted of phytochemical analysis with the combination between VCO and aqueous of Morinda Citrifolia linn extract , antioxidative activity analysis methods using DPPH and TBA and hepatoprotective in vivo test using wistar rats as test animals. The results showed that the phytochemical content of VCO combination with aqueous of Morinda Citrifolia Linn extract dominant are flavonoids, saponins and triterpenoids. Antioxidative activity: DPPH free radical capture with the combination of VCO and aqueous Morinda Citrifolia linn extract is very powerful with the effective concentration (EC50) 75.40 ppm compared with the positive control (BHT) the effective concentration is (EC50) 121.45 ppm. Based on the data-serum GPT activity and rat liver cell histology were found as well as the results of the analysis procedure is applied, it can be concluded that the combination of the VCO and the aqueous Morinda Citrifolia Linn extract has hepatoprotective characteristic with a dose range of 1.260 g / kg body weight up to 1,890 g / kg Keywords: hepatoprotective, Morinda Citrifolia Linn+ VCO combination, antioxidant
