This article details the case history of a 41-year-old patient who had undergone a cadaveric renal transplant in 1983 and developed myasthenia gravis in 1990 despite being on immunosuppressive treatment with prednisone, azathioprine, and cyclosporine. She responded to symptomatic therapy with pyridostigmine. This case report is of interest since the patient developed myasthenia while already being heavily immunosuppressed for prevention of transplant rejection