A major design requirement for transport aircraft is efficient cruise flight in the transonic region. From the aerodynamic viewpoint, this is achieved by favorable lift-to-drag ratio of the aircraft, both at the main design point and at off-design conditions. We therefore present a method to efficiently perform a multi-point optimization of a representative wing-body configuration. Designs are evaluated with RANS CFD simulations, the wing is parametrized using 40 free-form deformation control points, and a gradient-based method is used to drive the optimization. The gradient of cost functions is computed with a discrete adjoint approach, in which flow and mesh adjoint equations are solved. Compared to single-point optimization, with multi-point optimization we obtain a design with slightly lower best lift-to-drag ratio, but which has improved lift-to-drag polar over the whole range of practical lift coefficients compared to the baseline design
