The annual formation of the Northern Gulf of Mexico hypoxic zone is driven by nutrient loading from the Mississippi-Atchafalaya River Basin (MARB). Member States of The Mississippi River/Gulf of Mexico Hypoxia Task have developed statewide strategies to identify priorities and opportunities for nutrient export reduction in the MARB. In 2014, the State of Arkansas joined the Task Force and initiated an Arkansas Nutrient Reduction Strategy (ANRS), which currently prioritizes ten Hydrologic Unit Code 8 (HUC-8) watersheds (ANRD, 2014). These priority watersheds were not selected based on measured in-stream nutrient concentrations or trends, which impedes quantitative assessment, goal setting, and linking investments to nutrient reduction progress. The ANRS is currently under revision to address these concerns, and the goal of this project was to develop a prioritization framework for the State of Arkansas based on robust statistical analysis of extensive, statewide ambient water quality monitoring data sets