A one-pot five-component coupling of aryl aldehydes, aryl amines and β-keto ester affords functionalized piperidines I [R1 = C6H5, 4-FC6H4, 3,4,5-(OCH3)3C6H2; R2 = C6H5, 4-CH3C6H4; R3 = CH3, CH2CH3] under sonication (35 kHz) is developed. Cerium trichloride acts as a good catalyst and ultrasound acts as an excellent rate accelerator for this reaction resulting in good yield of the products