Background - Worldwide, tuberculosis (TB) is one of the top 10 causes
of death. Drug resistant tuberculosis has lately become a major public
health problem that threatens progress made in Tuberculosis (TB) care
and control worldwide. The aim of this study was to determine the
prevalence of Pre-extensive drug resistant TB among MDR TB in North
Central of Nigeria. Methods - This study was conducted from October,
2018 to August, 2019 with 150 samples. In Nigeria, guidelines for DR-TB
as recommended by WHO is followed. All the samples from the patients
who gave their consent were transported to a zonal reference TB
laboratory (ZRL). Results - Mean age was 38.6 \ub1 13.4 years with
peak age at 35-44. Out of these 103 samples processed with LPA,
101(98%) were rifampicin resistant and 2 were rifampicin sensitive,
99(96%) were INH resistant and 4 (4%) were INH sensitive, 5(5%) were
fluoroquinolone resistant, 98(95%) were fluoroquinolone sensitive, 12
(12%) were Aminoglycoside + Capreomycin resistant, 91(83%) were
Aminoglycoside + Capreomycin sensitive. Conclusion - Multidrug
resistant TB and its severe forms (Pre-extensive & extensively drug
resistant TB) can be detected early with rapid tool- Line Probe Assay
rapid and prevented timely by early initiation on treatment