Background: Hemophilia is an inherited genetic disease characterized by
the inability to coagulate blood after injury. The rationale of the
current study was to evaluate serum proteins S and C and correlate to
kidney function test in hemophilic patients for early diagnosis of
abnormality in renal function. Subjects and Methods: This study was
conducted on 80 males subjects divided into four groups. Group I:
Control: Healthy subjects. Group II: Renal dysfunction (serum
Creatinine >2mg/dl): Group III: Hemophilic patients. Group IV:
Hemophilic patients with renal disorder. Serum urea, creatinine,
sodium, potassium, protein C and protein S level were determined.
Resuts: Protein C and S levels showed a significant decrease in
hemophilic/and with renal dysfunction (P < 0.001,p<0.001). The
level of plasma protein C and S levels were positively correlated with
increased urinary albumin (P < 0.01). Urinary albumin was increased
about 15 folds in hemophilic patients with renal dysfunction and
nephrotic patients as compared with the control group. The cut-off
value in 90% patients at the hemophilic patients with renal dysfunction
70%. Positive correlations were observed between urinary albumin
(r=0.66), and creatinine (r=0.73). Conclusion: These biomarkers showed
good predictive values with regard to ROC-AUC (0.41 and 0.75 for
Proteins C and S, respectively)