Background: The relationship between metabolic syndrome (MetS) and
hyperuricemia is not fully understood. Objective: To examine the
association of hyperuricemia with MetS and the component of MetS that
is mostly influenced by hyperuricemia among university workers.
Methods: Anthropometric measurements, blood pressure, glucose, lipid
profiles, renal function tests were measured in 1198 male and 1075
female (22-60 years old) workers on annual medical examination.
Results: Hyperuricemia was 3-fold higher in males (odds ratio, OR,
2.938, 95% confidence interval, CI, 1.909-4.522, P<0.01) than
females after adjustment for age, body mass index (BMI) and renal
function. Overall, individuals with hyperuricemia were 3.9-fold likely
to have MetS OR, 3.903; CI (2.439-6.245), P<0.01, and dyslipidemia,
2.5 times (OR, 2.501; 95% CI, 1.776-3.521, P<0.01) after adjustment
for age, BMI, sex and renal function. However, no associations were
found in individuals with hypertension (OR, 1.427; 95% CI, 0.996-2.205,
P=0.052) and hyperglycemia (OR, 1.476; 95% CI, 0.989-2.202, P=0.057).
Administrative work positively associated (OR, 1.895; 95% CI,
1.202-2.925, P<0.05) with hyperuricemia in males and not females.
Conclusion: Male workers with hyperuricemia, especially those working
in administration were at risk of metabolic syndrome. It is important
to screen, prevent and treat metabolic syndrome in individuals
diagnosed with hyperuricemia at the workplace