Effect of dietary fat supplementation during late pregnancy and first
six months of lactation on maternal and infant vitamin A status in
rural Bangladesh
Dietary fat intake is extremely low in most communities with vitamin A
deficiency. However, its role in vitamin A status of pregnant and
lactating women is poorly understood. The aim of the study was to
examine the effect of supplementing women with fat from mid-/late
pregnancy until six months postpartum on their vitamin A status and
that of their infants. Women recruited at 5-7 months of gestation were
supple-mented daily with 20 mL of soybean-oil (n=248) until six months
postpartum or received no supplement (n=251). Dietary fat intake was
assessed by 24-hour dietary recall at enrollment and at 1, 3 and 6
months postpartum. Concentrations of maternal plasma retinol,
\u3b2-carotene, and lutein were measured at enroll-ment and at 1, 3
and 6 months postpartum, and those of infants at six months postpartum.
Concentration of breastmilk retinol was measured at 1, 3 and 6 months
postpartum. The change in concentration of plasma retinol at three
months postpartum compared to pregnancy was significantly higher in the
supple-mented compared to the control women (+0.04 vs -0.07 \u3bcmol/L
respectively; p<0.05). Concentrations of plasma \u3b2-carotene and
lutein declined in both the groups during the postpartum period but the
decline was significantly less in the supplemented than in the control
women at one month \u3b2-carotene -0.07 vs -0.13 \u3bcmol/L,
p<0.05); lutein -0.26 vs -0.49 \u3bcmol/L, p<0.05) and three
months \u3b2-carotene -0.04 vs -0.08 \u3bcmol/L, p<0.05; lutein
-0.31 vs -0.47 \u3bcmol/L, p<0.05). Concentration of breastmilk
retinol was also signifi-cantly greater in the supplemented group at
three months postpartum than in the controls (0.68\ub10.35 vs
0.55\ub10.34 \u3bcmol/L respectively, p<0.03). Concentrations of
infants\u2032 plasma retinol, \u3b2-carotene, and lutein, measured at
six months of age, did not differ between the groups. Fat
supplementation during pregnancy and lactation in women with a very low
intake of dietary fat has beneficial effects on maternal postpartum
vitamin A status