Medknow Publications on behalf of Indian Society of Human Genetics
Abstract
Receptors for the Fc domains of IgG (Fc \u3b3 R) play a critical role
in linking humoral and cellular immune responses. The various Fc \u3b3
R genes may contribute to differences in infectious and immune related
diseases in various ethnic populations. Polymorphisms of Fc \u3b3 R
mainly Fc \u3b3 R IIA, IIB, IIIA, IIIB have been identified as genetic
factors influencing susceptibility to disease or disease course of a
prototype autoimmune disease like Systemic Lupus Erythematosus (SLE).
Activated and inhibitory Fc \u3b3 Rs seem to play an important role in
the pathogenesis of SLE, in initiation of autoimmunity, the subsequent
development of inflammatory lesions and finally immune clearance
mechanisms. This review focuses on the role of Fc \u3b3 R polymorphism
and their association with clinical manifestations and initiation of
autoantibody production, inflammatory handling of immune complexes and
disease development in SLE patients