Medknow Publications on behalf of Indian Society of Human Genetics
Abstract
Dyslexia is a hereditary neurological disorder that manifests as an
unexpected difficulty in learning to read despite adequate
intelligence, education, and normal senses. The prevalence of dyslexia
ranges from 3 to 15% of the school aged children. Many genetic studies
indicated that loci on 6p21.3, 15q15-21, and 18p11.2 have been
identified as promising candidate gene regions for dyslexia. Recently,
it has been suggested that allelic variants of gene, DYX1C1 influence
dyslexia. In the present study, exon 2 and 10 of DYX1C1 has been
analyzed to verify whether these single nucleotide polymorphisms (SNPs)
influence dyslexia, in our population. Our study identified 4 SNPs
however, none of these SNPS were found to be significantly associated
with dyslexia suggesting DYX1C1 allelic variants are not associated
with dyslexia