Póster presentado al IX Meeting of the Spanish Society for Developmental Biology celebrado en Granada del 12 al 14 de noviembre de 2012.A key issue in developmental
biology is the relationship
between cell polarity and
signal transduction pathways.
Most eukaryotic cells
are polarized with an
asymmetric distribution
of molecules and organelles
resulting in different
functional regions required
for cell physiology. The control
of this polarity in space and
time is essential to coordinate
changes in cell morphology
with proliferation and
morphogenetic movements
required for the development
of the organism. This control
is carried out by signalling pathways, which in many
cases are regulated by the
subcellular localization of
their components. In fact,
there is a close relationship
between polarity and the
control of cell proliferation,
since many receptors of
intercellular communication
pathways that regulate proliferation are located and
activated in specific domains
of the plasma membrane.
Therefore, the understanding
of the signalling pathways‐cell
polarity relationship is crucial
for the knowledge of how
signals are integrated to
induce morphogenesis but
also how are modified in
aberrant processes as
those occurring in cancer.
The atypical protein kinase
C (aPKC) is a crucial protein
in the cell polarity
establishment or maintenance
and also can participate in
many other processes in
the cell. aPKC has an
enzymatic activity and
can regulate different
signaling pathways in the cell. In
all these processes aPKC
interact, depending on the
process, with different regulators
and modifies different substrates.
In addition, aPKC is an
oncogene. To understand
how cell polarity is established,
maintained and modified and
also how this polarity can regulate
signalling processes we have
focused on to find out new
proteins that interact with
aPKC.Peer Reviewe
