Resumen del trabajo presentado al 4th Spanish Worm Meeting, celebrado en Carmona (Sevilla) del 14 al 15 de marzo de 2013.A reduction of food intake without malnutrition increases longevity in almost any of the
model animals where have been tested. In order to understand this process our group has
isolated a collection of mutants that are long lived even in normal diet. One of those
mutants is gale-1(pv18) which encoded to a UDP-4-galactosa-epimerase. This mutant, in
addition to be long lived, show morphological organ defects, probably due to an alteration
in the concentration of UDP-sugars. In humans, mutation in the homologue gene to gale-1
generate a rare disease known as galactosemia type III, the characterization of this
mutant may help to better understand this disease in humans.Peer Reviewe