Sugar and longevity in gale-1 mutant

Abstract

Resumen del trabajo presentado al 4th Spanish Worm Meeting, celebrado en Carmona (Sevilla) del 14 al 15 de marzo de 2013.A reduction of food intake without malnutrition increases longevity in almost any of the model animals where have been tested. In order to understand this process our group has isolated a collection of mutants that are long lived even in normal diet. One of those mutants is gale-1(pv18) which encoded to a UDP-4-galactosa-epimerase. This mutant, in addition to be long lived, show morphological organ defects, probably due to an alteration in the concentration of UDP-sugars. In humans, mutation in the homologue gene to gale-1 generate a rare disease known as galactosemia type III, the characterization of this mutant may help to better understand this disease in humans.Peer Reviewe