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An iron-based T 1 contrast agent made of iron-phosphate complexes: In vitro and in vivo studies
Authors
Carles Arús
Miquel E. Cabañas
+6 more
Sebastián Cerdán
María L. García-Martín
Elies Molins
Elisenda Rodríguez
Anna Roig Serra
Coral Sanfeliu
Publication date
10 September 2013
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
Abstract
et al.A new iron-based T 1 contrast agent consisting of a complex of iron ions coordinated to phosphate and amine ligands (Fe(phos) in short) has been characterized by spectroscopic and magnetic measurements. NMR relaxation studies showed r 1 values to be dependent on the phosphate salt concentration, K2HPO4, present in the medium. r 1 reaches a maximum value of 2.5 mM-1 s-1 for measurements carried out at 7 T and 298 K. 31P MRS, Mössbauer spectroscopy and magnetic measurements of Fe(phos) solutions suggest paramagnetic Fe3+ ions present in the studied iron-phosphate complex. In vitro and in vivo toxicity experiments with C6 cells and CD1 mice, respectively, demonstrated lack of toxicity for Fe(phos) at the highest dose tested in the MRI experiments (12 mM iron for C6 cells and 0.32 mmol iron/kg for mice). Finally, T 1 weighted images of brain tumours in mice have shown positive contrast enhancement of Fe(phos) for tumour afflicted regions in the brain. © 2007 ESMRMB.This work was funded by: Ministerio de Ciencia y Tecnología (MCYT SAF 2002-0440 and MCYT MAT 2003-01052), Ministerio de Educación y Ciencia (MEC SAF 2005-03650), Fondo de Investigaciones Sanitarias (2003-0467), Fundação para a Ciência e a Tecnologia (SFRH/BD/17643/2004).Peer Reviewe
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Last time updated on 25/05/2016