Transgender includes patients at various stages of their journey. It is important that providers care for transgender patients with a culturally sensitive approach, awareness, and competent skill. There are new terms to learn. There may be mental health issues or substance use issues. Hormone therapy can have an impact on a person’s health. As a primary care provider, it is important to be alert to these potential issues, addressing the patient’s individual needs. In this study we discuss the transgender patient and outline basic care and issues that can arise in a primary care setting