CD4+ T- cell count and CD4/CD8 ratio trend after HCV eradication in HCV/HIV-coinfected subjects treated with DAAs: an observational retrospective study over a 4 year period.

Abstract

Immune activation and inflammation due to HIV infection is currently considered the driving force of CD4+ T-cell depletion and of the functional impairment of the immune system [1]. o Hepatitis C virus (HCV) coinfection, has been suggested as contributing to immune activation. Since direct-acting antiviral agents (DAAs) has been introduced, HCV has been treated and eradicated in a large proportion of HIV/HCV- coinfected patients. However, the impact that HCV eradication has on immune activation and immune recovery is still unclear [1-3]. o We want to investigate CD4+, CD8+ T-cell count, and CD4/CD8 ratio trend in cirrhotic and not-cirrhotic HIV/HCV-coinfected patients after DAAs treatment and HCV eradication