CD4+ T- cell count and CD4/CD8 ratio trend after HCV eradication in HCV/HIV-coinfected subjects treated with DAAs: an observational retrospective study over a 4 year period.
Immune activation and inflammation due to HIV
infection is currently considered the driving
force of CD4+ T-cell depletion and of the
functional impairment of the immune system [1].
o
Hepatitis C virus (HCV) coinfection, has been
suggested as contributing to immune activation.
Since direct-acting antiviral agents (DAAs) has
been introduced, HCV has been treated and
eradicated in a large proportion of HIV/HCV-
coinfected patients. However, the impact that
HCV eradication has on immune activation and
immune recovery is still unclear [1-3].
o
We want to investigate CD4+, CD8+ T-cell
count, and CD4/CD8 ratio trend in cirrhotic and
not-cirrhotic HIV/HCV-coinfected patients after
DAAs treatment and HCV eradication