Background:
Cognitive deficits are core features of Schizophrenia, showing poor response to antipsychotic treatment, therefore non-pharmacological
rehabilitative approaches to such a symptom domain need to be identified. However, since not all patients with Schizophrenia exhibit the same
cognitive impairment profile, individualized rehabilitative approaches should be set up.
Objectives:
We explored the last five-year literature addressing the issue of cognitive dysfunction response to rehabilitative methodologies in Schizophrenia to
identify possible predictors of response and individualized strategies to treat such a dysfunction.
Conclusion:
A total of 76 studies were reviewed. Possible predictors of cognitive rehabilitation outcome were identified among patient-specific and approachspecific variables and a general overview of rehabilitative strategies used in the last five years has been depicted. Studies suggest the existence of
multifaced and multi-domain variables that could significantly predict pro-cognitive effects of cognitive rehabilitation, which could also be useful
for identifying individual-specific rehabilitation trajectories over time.
An individualized rehabilitative approach to cognitive impairment in Schizophrenia is possible if taking into account both patient and approach
specific predictors of outcomes
