Abstract no. EM-07published_or_final_versio

Fong, D

Lam, KSL

Lee, KK

Leung, E

Tam, SCF

Wong, S

Wong, V

Hong Kong Medical Journal

HKU Scholars Hub

TitleThe beneficial effects of Qigong and conventional exercise onblood pressure and anthropometric indices in type 2 Chinesediabetic patientsAuthor(s) Lee, KK; Leung, E; Fong, D; Wong, S; Tam, SCF; Wong, V; Lam,KSLCitationThe 8th Medical Research Conference, Medical Science Group,The University of Hong Kong, Queen Mary Hospital, Hong Kong,25-26 January 2003, v. 9 n. 1 Suppl, p. 34Issued Date 2003URL http://hdl.handle.net/10722/53989Rights Creative Commons: Attribution 3.0 Hong Kong License34      HKMJ Vol 9 No 1 February 2003 SupplementEM-08 The effect of glycoxidized LDL on monocytes/ macrophages cell line (THP-1) geneexpressionCW Lam, KCB Tan and KSL Lam, Department of Medicine, Faculty of Medicine, The University of Hong KongIntroduction: Cardiovascular complications are the leading cause of morbidity and morality in patients with diabe-tes mellitus. Epidemiological studies have shown that hyperglycemia and dylipidemia are two risk factors fordiabetic atherosclerosis. Lipoprotein is subjected to both glycation and oxidation in diabetes. The biological effectsof glycoxidized LDL have not been well characterized. The objective of this study is to investigate whetherglycoxidized LDL induce the gene expression of human monocyte/macrophages, using the THP-1 cell line, bymodified lipoprotein.Methods: Glycoxidized LDL was obtaining by incubating LDL with glucose and copper ion for 7 days. The extentof oxidation was measured by TBARS assay. Monocytes/ macrophages cell (THP-1) was incubated with glycoxidizedLDL for one day. The gene expressions were quantified using quantative PCR.Results: The oxidation of glycoxidized LDL was significantly higher than native LDL (7.12+2.7 nmol MDA/mgprotein versus 1.615+0.459 nmol MDA/mg protein). The gene expression of CD36 has been upregulated by 4.6+1.09folds when incubated with glycoxidized LDL at 100ug/ml. The gene expression of SR-BI was suppressed byglycoxidized LDL by 4.8+1.64 folds.Conclusion: Glycoxidized LDL regulate the gene expression of CD36 which may increase the binding and inter-nalization of modified LDLs by macrophages. Down regulation of SR-BI may lead to a decrease in cholesterolefflux. These gene expression profiles have suggested some potential mechanisms for the contribution of modifiedLDL to the development of diabetic atherosclerosis.The beneficial effects of Qigong and conventional exercise on blood pressure andanthropometric indices in type 2 Chinese diabetic patientsLee KK1, Leung E1, Fong D2, Wong S3, Tam SCF4, Wong V5 and Lam KSL1Department of Medicine1, Clinical Trials Centre2, The University of Hong Kong; Physiotherapy3, Clinical Biochemistry Unit4 andAdministration5, Queen Mary Hospital, Hong Kong SAR.Introduction: Exercise is generally accepted as a cornerstone of diabetes management, because it promotes caloricexpenditure and improves insulin sensitivity. Qigong is an alternative exercise program, widely practiced in China,which is believed to have the effect of self-regulating various functional activities of the body, leading to alterationsin metabolic rate and potential benefits on glycaemic control. In this study we investigated the effects of qigongversus conventional exercise in 100 Chinese type 2 diabetic patients with suboptimal glycaemic control.Method: Patients were randomised to either of 2 groups, to learn and practice the scheduled conventional exerciseor qigong program with matched exercise intensity for 18 weeks, under the supervision of a physiotherapist andqigong therapist, respectively. They were also instructed to practice it at home. All medications remained un-changed throughout the study.Results: During the study period neither group showed any significant improvement in HbA1c or insulin sensitiv-ity as measured by HOMA or QUICKI. Qigong had a superior effect on HDL-C, with a significantly larger propor-tion of subjects having a HDL-C>0.9mmol/l at the end of the study (OR=1.84; p=0.023 versus conventional exercise),but a smaller proportion of subjects maintaining a BMI<23 (OR=0.7; p=0.038). When data from the two groupswere combined, an improvement in both systolic and diastolic blood pressure was observed, increasing in magni-tude as the study progressed (sBP: -3.42±1.37, p=0.012 at week 10 and –4.52±1.57, p=0.004 at week18;dBP: -3.23±0.98, p=0.001 at week 10 and –5.07±1.15, p<0.001 at week 18). Similar reductions in waist and hipcircumferences were also noted (waist: -0.32±0.12cm, p=0.006 at week 10 and –0.49±0.16cm, p=0.002 at week 18;hip: -0.30±0.11cm, p=0.006 at week 10 and –0.38±0.16cm, p=0.015 at week 18).Conclusion: We concluded that long-term exercise, either qigong or conventional exercise, was associated withbeneficial effects on various aspects of the metabolic syndrome in patients with type 2 diabetes.Acknowledgement: This study was supported by funding from the Li Ka Shing Foundation.EM-07

The beneficial effects of Qigong and conventional exercise on blood pressure and anthropometric indices in type 2 Chinese diabetic patients

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The beneficial effects of Qigong and conventional exercise on blood pressure and anthropometric indices in type 2 Chinese diabetic patients

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