Chiu, PKY

Chu, MY

Lau, CS

Wong, RWS

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TitleOutcome measures of chronic arthritis in Hong Kong:comparison of the AIMS2 (Chinese) and WHO quality of life -brief form (WHOQOL-BREF) (HK)Author(s) Chu, MY; Chiu, PKY; Lau, CS; Wong, RWSCitation The 5th Medical Research Conference, Hong Kong, China,January 2000, v. 22 n. Supp 2, p. 25Issued Date 2000URL http://hdl.handle.net/10722/46938Rights Creative Commons: Attribution 3.0 Hong Kong LicenseG-RI-1OUTCOME MEASURES OF CHRONIC ARTHRITIS IN HONG KONG: COMPARISON OF THEAIMS2 (CHINESE) AND WHO QUALITY OF LIFE - BRIEF FORM (WHOQOL-BREF) (HK)MY Chu. PKY Chiu, CS Lau and RWS Wong, Departments of Medicine and Orthopaedic Surgery, TheUniversity of Hong KongObjective: We have recently shown the AIMS2 (Chinese) is a reliable health status measurement tool forChinese speaking arthritis patients. The WHOQOL-BREF (HK) has been validated as a QOL measurementtool in Chinese. The aim of this study was to compare the AIMS2 (Chinese) and the WHOQOL-BREF (HK)as an assessment tool to study the quality of life (QOL) of Chinese speaking subjects with chronic arthritis.Method: The WHOQOL-BREF (HK) and AIMS (Chinese) questionnaires were administered concurrently to157 subjects [RA=64; OA=l8; healthy subjects =75]. The 12 sub-scales scores of the AIMS2 (Chinese) andthe domain scores of WHOQOL-BREF (HK) were compared.Results: Chronic arthritis patients had significantly poorer WHOQOL-BREF (HK) physical health [p=0.()00]and psychological health scores [p=0.002] when compared with healthy subjects. AIMS2 (Chinese) performedwell against the WHOQOL-BREF (HK) in QOL assessments. (1) There was significant correlation betweenthe WHOQOL-BREF (HK) physical domain and the AIMS (Chinese) mobility [r=0.488], walking and bendinglr=0.6391, hand and finger function [r=0.361], arm function [r=0.398], arthritis pain [r=0.676], self-care abilityIr=0.2931, household task [r=0.265] and work [r=0.329] sub-scales. (2) The WHOQOL-BREF (HK)psychological domain correlated significantly with the AIMS2 (Chinese) tension [r=0.498] and mood [r=0.582]sub-scales. (3) Significant correlation was also observed between the WHOQOL-BREF (HK) social relationshipdomain and the AIMS (Chinese) social activities [r=0.301] and support from family and friends [r=0.240] sub-scales.Conclusion: Patients with chronic arthritis have poorer QOL when compared with healthy subjects. AIMS2(Chinese) is a reliable QOL assessment tool when compared with WHOQOL-BREF (HK), a previously validatedtool, in Chinese speaking patients with chronic arthritis.G-R1-2INHIBITION OF SYNOVIAL FIBROBLAST PRODUCTION OF IL-6 BY TRIPTOLIDE, AN ACTIVEINGREDIENT OF TRYTERYGIUM WILFORDII HOOK FJ Yeung. KK Tong, A Chan, CS Lau. Department of Medicine, The University of Hong Kong, Hong Kong,SAR, ChinaObjective: Triptolide (Tr) is an active ingredient of a Chinese herb, Trypterygium Wilfordii Hook f, that iswidely used in China as an anti-rheumatic drug. We have previously shown Tr has suppressive as well ascytotoxic effects on immune effects, and for the first time, that Tr inhibits synovial cell growth. We have alsobeen engaged in the synthesis of analogues of Tr. This study aimed to examine the effects of Tr and selectedanalogues (based on biological effects) - T59 and T60, on IL-6 production by human fibroblast-like synoviocytes(FLSs).Methods: Synovial tissues were obtained from rheumatoid arthritis patients at the time of synovectomy ortotal knee replacement. Following removal of fat and collagen tissues, the synovial cells were cultured for 2days. Tr or T59 or T60 at various concentrations were added. IL-lp (1 ng/ml) was added after 24 hours. Thesupernatant was removed at the end of day 2. The concentration of IL-6 in the supernatant was measured byELISA.Results: Tr, at concentrations above 10 nM, produced a dose dependent inhibitory effect on IL-lp-inducedsynthesis of IL-6 by FLSs. The concentration of Tr required to cause a 50% inhibition of IL-6 synthesis was30 nM. Similar results were obtained with T59 and T60.Conclusion: This study has further confirmed that Tr has direct effects on FLSs function. It also confirms thatour route of Tr analogue synthesis is promising, and helps us to determine the chemical structure(s) of Tr thatis important for its functions. Further studies will focus on the mechanism of action, such as the signaltransduction pathway, of IL-6 synthesis inhibition by Tr.- 25 -

Outcome measures of chronic arthritis in Hong Kong: comparison of the AIMS2 (Chinese) and WHO quality of life - brief form (WHOQOL-BREF) (HK)

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Outcome measures of chronic arthritis in Hong Kong: comparison of the AIMS2 (Chinese) and WHO quality of life - brief form (WHOQOL-BREF) (HK)

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