No abstract available.https://www.frontiersin.org/journals/physiologydm2022Physiolog

Bester, Janette

Swanepoel, Albe Carina

Windberger, Ursula

PubMed

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Editorial: Pathological Changes inErythrocytes During Inflammation andInfectionJanette Bester1*, Albe Carina Swanepoel2 and Ursula Windberger31Department of Physiology, University of Pretoria, Pretoria, South Africa, 2Centre of Excellence for Nutrition, North-WestUniversity, Potchefstroom, South Africa, 3Core Facility Laboratory Animal Breeding and Husbandry, Medical University Vienna,Vienna, AustriaKeywords: erythrocyte (RBC), inflammation, COVID-19, malaria, rheologyEditorial on the Research TopicPathological Changes in Erythrocytes During Inflammation and InfectionThis Research Topic focused on the pathological changes in erythrocytes during infection orinflammation. It has been shown that during inflammation, erythrocytes can undergo bothbiochemical, as well as biophysical alterations (Pretorius, 2018). Biochemical changes can beseen as disruptions in the molecular arrangement of the plasma membrane and erythrocytefunction, whereas biophysical changes are noted as changes to the general structuralarrangement and erythrocyte morphology, translating to changes in erythrocyte mechanics(Bester and Pretorius, 2016; Pretorius et al., 2016; Page et al., 2018). Generally, inflammatorymolecules interact with erythrocyte membranes, leading to structural changes (Lang et al., 2006; Langet al., 2012).The articles published in this Research Topic elucidated how inflammation and infection play arole in altering erythrocyte metabolism, mechanics, and function. One of these articles is byMaruyama et al., which reviewed the rheological abnormalities of erythrocytes subjected tooxidative inflammation. It was noted that in diabetes mellitus the erythrocytes show anenhanced prothrombotic tendency, based on changes in cell deformability, aggregability, andmembrane fluidity. Also, in hypertension, the reduction of erythrocyte deformability becomesproportional to the mean blood pressure of patients on treatment. In conclusion, the authors statedthat the impairment of erythrocytes in circulation disrupts systemic microcirculation and inducestissue hypoxia.Another two articles addressed the changes of erythrocytes seen in COVID-19 infected patientsand associated disease severity (Bouchla et al.; Piagnerelli et al.). Bouchla et al. indicated that thevirus-induced erythrocyte oxidative stress increased intracellular Ca2+ levels which resulted inhigher erythrocyte fragility. In the study from Piagnerelli et al., it was shown that there was nochange in erythrocyte deformability in relation to disease severity, however, these cells did showalterations in shape and were spherically shaped on day-7 of infection. The authors connected thepreservation of normal deformability with the microcirculatory response to hypoxia in theirpatients. In essence, these two articles indicate that notable changes can occur in erythrocytes inpatients infected with COVID-19 which contribute to the complications associated with thedisease.On the other hand, multiple erythrocyte alterations have been described during malaria,including decreased deformability that correlated with disease severity (Malaria, 2005;Jauréguiberry et al., 2014). Anemia has been shown to be the leading cause of morbidity andmortality in malaria, some of them due to treatment (Price et al., 2001). Here Chambrion et al.Edited and reviewed by:Lars Kaestner,Saarland University, Germany*Correspondence:Janette Besterjanette.bester@up.ac.zaSpecialty section:This article was submitted toRed Blood Cell Physiology,a section of the journalFrontiers in PhysiologyReceived: 13 May 2022Accepted: 02 June 2022Published: 17 June 2022Citation:Bester J, Swanepoel AC andWindberger U (2022) Editorial:Pathological Changes in ErythrocytesDuring Inflammation and Infection.Front. Physiol. 13:943114.doi: 10.3389/fphys.2022.943114Frontiers in Physiology | www.frontiersin.org June 2022 | Volume 13 | Article 9431141EDITORIALpublished: 17 June 2022doi: 10.3389/fphys.2022.943114explored the changes in infected erythrocyte subpopulations ofpatients under treatment with artemisinin derivatives (AD).The data showed that infection by P. falciparum inducedmodification of the proteins and the lipids located in theerythrocyte plasma membrane and the cytosol, subsequentlycausing reduced deformability related to splenic retention andclearance. These modifications were still prevalent aftertreatment. Not only did infection and treatment profoundlyaffect certain erythrocyte subpopulations it also had a largeeffect on never infected erythrocyte populations. Chambrionet al. explained that this might be why the magnitude of neverinfected erythrocytes lost is frequently higher than infectederythrocytes in malaria anaemia. In conclusion, it was said thatinfection with P. falciparum, artesunate treatment, and pittingtriggered alterations in the biochemical properties ofcirculating erythrocytes, and that early post-treatmentanaemia is mostly due to the clearance of never infectederythrocytes.From this Research Topic, it is clear that erythrocytes areaffected in many conditions and contribute to the complicationsassociated with these conditions. It is obvious that erythrocytechanges are triggered by endogenous challenges induced by thedifferent conditions and that it contributes to the relatedcomplications. Nonetheless, our knowledge about mechanismsunderlying these changes and the implications are still incomplete(Lang et al., 2012).AUTHOR CONTRIBUTIONSJB, AS, and UW performed editorial duties for this ResearchTopic. All the authors contributed to the writing of the editorial.REFERENCESBester, J., and Pretorius, E. (2016). Effects of IL-1β, IL-6 and IL-8 onErythrocytes, Platelets and Clot Viscoelasticity. Sci. Rep. 6, 32188. doi:10.1038/srep32188Jauréguiberry, S., Ndour, P. A., Roussel, C., Ader, F., Safeukui, I., Nguyen, M., et al.(2014). Postartesunate Delayed Hemolysis Is a Predictable Event Related to theLifesaving Effect of Artemisinins. Blood 124 (2), 167–175. doi:10.1182/blood-2014-02-555953Lang, F., Lang, K. S., Lang, P. A., Huber, S. M., andWieder, T. (2006). Mechanismsand Significance of Eryptosis.Antioxid. Redox Signal 8 (7-8), 1183–1192. doi:10.1089/ars.2006.8.1183Lang, F., Lang, E., and Föller, M. (2012). Physiology and Pathophysiology ofEryptosis. Transfus. Med. Hemother 39 (5), 308–314. doi:10.1159/000342534Malaria, S. E. A. Q. A. (2005). Artesunate versus Quinine for Treatment ofSevere Falciparum Malaria: a Randomised Trial. Lancet 366 (9487),717–725. doi:10.1016/S0140-6736(05)67176-0Page, M. J., Bester, J., and Pretorius, E. (2018). The Inflammatory Effects of TNF-αand Complement Component 3 on Coagulation. Sci. Rep. 8 (1), 1812–1819.doi:10.1038/s41598-018-20220-8Pretorius, E., du Plooy, J. N., and Bester, J. (2016). A Comprehensive Reviewon Eryptosis. Cell Physiol. Biochem. 39 (5), 1977–2000. doi:10.1159/000447895Pretorius, E. (2018). Erythrocyte Deformability and Eryptosis duringInflammation, and Impaired Blood Rheology. Clin. Hemorheol. Microcirc.69 (4), 545–550. doi:10.3233/ch-189205Price, R. N., Luxemburger, C., Simpson, J. A., Hkirjaroen, L., Nosten, F., White, N.J., et al. (2001). Factors Contributing to Anemia after UncomplicatedFalciparum Malaria. Am. J. Trop. Med. Hyg. 65 (5), 614–622. doi:10.4269/ajtmh.2001.65.614Conflict of Interest: The authors declare that the research was conducted in theabsence of any commercial or financial relationships that could be construed as apotential conflict of interest.Publisher’s Note: All claims expressed in this article are solely those of the authorsand do not necessarily represent those of their affiliated organizations, or those ofthe publisher, the editors, and the reviewers. Any product that may be evaluated inthis article, or claim that may be made by its manufacturer, is not guaranteed orendorsed by the publisher.Copyright © 2022 Bester, Swanepoel and Windberger. This is an open-access articledistributed under the terms of the Creative Commons Attribution License (CC BY).The use, distribution or reproduction in other forums is permitted, provided theoriginal author(s) and the copyright owner(s) are credited and that the originalpublication in this journal is cited, in accordance with accepted academic practice.No use, distribution or reproduction is permitted which does not comply withthese terms.Frontiers in Physiology | www.frontiersin.org June 2022 | Volume 13 | Article 9431142Bester et al. Editorial: Erythrocytes During Inflammation and Infection

Editorial : Pathological changes in erythrocytes during inflammation and infection

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Editorial: Pathological Changes in Erythrocytes During Inflammation and Infection

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Editorial : Pathological changes in erythrocytes during inflammation and infection

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