There is a growing concern over change in vegetation dynamics and drought patterns with the increasing climate variability and warming trends in Africa, particularly in the semiarid regions of East Africa. Here, several geospatial techniques and datasets were used to analyze the spatio-temporal vegetation dynamics in response to climate (precipitation and temperature) and drought in Eritrea from 2000 to 2017. A pixel-based trend analysis was performed, and a Pearson correlation coefficient was computed between vegetation indices and climate variables. In addition, vegetation condition index (VCI) and standard precipitation index (SPI) classifications were used to assess drought patterns in the country. The results demonstrated that there was a decreasing NDVI (Normalized Difference Vegetation Index) slope at both annual and seasonal time scales. In the study area, 57.1% of the pixels showed a decreasing annual NDVI trend, while the significance was higher in South-Western Eritrea. In most of the agro-ecological zones, the shrublands and croplands showed decreasing NDVI trends. About 87.16% of the study area had a positive correlation between growing season NDVI and precipitation (39.34%, p < 0.05). The Gash Barka region of the country showed the strongest and most significant correlations between NDVI and precipitation values. The specific drought assessments based on VCI and SPI summarized that Eritrea had been exposed to recurrent droughts of moderate to extreme conditions during the last 18 years. Based on the correlation analysis and drought patterns, this study confirms that low precipitation was mainly attributed to the slowly declining vegetation trends and increased drought conditions in the semi-arid region. Therefore, immediate action is needed to minimize the negative impact of climate variability and increasing aridity in vegetation and ecosystem services
