Is there a place in scientific inquiry for guessing? Jonathan Cohen has recently argued that resorting to guesswork entails a loss of objectivity and regard for evidence which are essential to proper scientific investigation. I assess the merits of Cohen’s view first by taking as a test case Aristotle’s positive view of the role of guesswork (anchinoia) and conjecture (eustochia) in the search for the connections essential to the construction of scientific demonstrations. I then argue contra Cohen that one can usefully employ guesswork while also employing reason; that it is possible to guess either intelligently or mindlessly; and consequently, that the use of guesswork need not represent a diminution in respect for the objectivity essential to scientific investigation. Although I would not claim that guesswork has a role to play in all scientific inquiry, there appear to be some datable instances of the useful and respectable scientific guess
