Annual European Congress of Rheumatology (EULAR) -- JUN 12-15, 2019 -- Madrid, SPAIN[No Abstract Available]European League Against Rheumatis

Bilge, Nazife Sule Yasar

Erden, Abdulsamet

Ertenli, Ali İhsan

İlgen, Ufuk

Kalyoncu, Umut

Kiraz, Sedat

Küçükşahin, Orhan

Mercan, Rıdvan

Annals of the Rheumatic Diseases

English

Namik Kemal University Institutional Repository

patients. A personal history of Reiter’s syndrome was noted in 2.22% ofpatients and of uveitis in 6.66%. Morning stiffness was noted in 60%(n=27) of patients. Good response to nonsteroidal anti-inflammatory drugs(NSAIDs) and to physical activity were respectively reported by 42.22%(n=19) and 57.8% (n=26) of patients. Twenty-seven per cent of thepatients were HLA-B27+. Fifty-one per cent of the studied patients fulfilledthe ASAS criteria for axial SpA and 46.7% fulfilled the Amor criteria.After a follow-up between 2 and 3 years, the diagnosis of SpA was con-firmed by the referring rheumatologists in 31 (68.9%) patients andexcluded in 14 (31.1%) patients. Among the 31 patients with confirmedSpA, 61.3% (n=19) had a positive US (with a mean RI estimated at0.75) and 38.7% (n=12) had a normal US. Among the 14 patients inwhom SpA was excluded, 50% (n=7) had a positive US (with a meanRI estimated at 0.7) and 50% had a normal US. Sensitivity and specific-ity of US examination were estimated at 61.3% and 50%. Positive andnegative likelihood ratio were estimated at 73% and 36.8%. Associationbetween US findings and rheumatologists’ diagnosis of SpA was not stat-istically significant (p=0.47).Conclusion: US contribution in the diagnostic of SpA has been little-studied. In our study, although US of SIJ lacked specificity, it has a sat-isfactory sensitivity and positive likehood ratio. In fact, this tool is morevaluable by its positivity which indicates a high probability of sacroiliitis.However, further investigation is needed in order to assess its perform-ance for ascertaining sacroiliitis.Disclosure of Interests: None declaredDOI: 10.1136/annrheumdis-2019-eular.6346AB0723 SMOKING MAY BE RELATED TO SACROILIITIS INENTEROPATHIC ARTHRITIS PATIENTS: TREASUREREAL-LIFE PRELIMINARY DATAOrhan Küçükşahin1, Abdulsamet Erden2, Ufuk İlgen3, Sedat Kiraz2, Aliİhsan Ertenli2, Nazife Sule Yasar Bilge4, Timuçin Kaşifoğlu4,Ediz Dalkılıç5,Cemal Bes6, Nilüfer Alpay Kanıtez7, Hakan Emmungil3, Pamir Atagündüz8,9,BelkisNihan Seniz5, Burcu Yağız5, Süleyman Serdar Koca10, Muhammet Çınar11,Aşkın Ateş12, Servet Akar13,Önay Gerçik13, Duygu Ersözlü14, Veli Yazısız15,Gezmiş Kimyon16, Müge Aydın17, Rıdvan Mercan18, Burak Öz10, ZeynelAbidin Akar10, Omer Karadag2, Bahar Keleşoğlu12,Sedat Yılmaz11,Yavuz Pehlivan5, Ender Terzioğlu15, Levent Kılıç2, Sukran Erten19,Koray Taşçılar20, Umut Kalyoncu2. 1Ankara Liv Hospital, Rheumatology, Ankara,Turkey; 2Hacettepe University Faculty of Medicine, Rheumatology, Ankara, Turkey;3Trakya University Faculty of Medicine, Rheumatology, Edirne, Turkey; 4EskisehirOsmangazi University Medical Faculty, Rheumatology, Eskişehir, Turkey; 5UludagUniversity Faculty of Medicine, Rheumatology, Bursa, Turkey; 6University of HealthSciences Bakırköy Sadi Konu education and research hospital, Rheumatology,İstanbul, Turkey; 7Koç University, Rheumatology, İstanbul, Turkey; 8MarmaraUniversity, Rheumatology, İstanbul, Turkey; 9Marmara University Faculty ofMedicine, Rheumatology, İstanbul, Turkey; 10Fırat University Faculty of Medicine,Rheumatology, Elazığ, Turkey; 11University of Health Sciences Gülhane Trainingand Research Hospital, Rheumatology, Ankara, Turkey; 12Ankara UniversityFaculty of Medicine, Rheumatology, ankara, Turkey; 13Katip Çelebi UniversityFaculty of Medicine, Rheumatology, İzmir, Turkey; 14Adana State Hospital,Rheumatology, Adana, Turkey; 15Akdeniz University Faculty of Medicine,Rheumatology, Antalya, Turkey; 16Mustafa Kemal University faculty of Medicine,Rheumatology, Hatay, Turkey; 17Başkent University Faculty of Medicine,Rheumatology, Adana, Turkey; 18Namık Kemal University Faculty of Medicine,Rheumatology, Tekirdağ, Turkey; 19Yıldırım Beyazıt University Faculty of Medicine,Rheumatology, Ankara, Turkey; 20Okmeydanı research and educational Hospital,Rheumatology, istanbul, TurkeyBackground: Articular manifestations may differ in ulcerative colitis (UC)and Crohn’s disease (CD). Genetic and non-genetic factors like sex,smoking, and presence of HLA-B27 were previously shown to modify theexpression of articular and other extraintestinal manifestations of IBD.Objectives: The aim of this study is to document disease features andfactors affecting the expression of articular manifestations in Turkishpatients with IBD-related (enteropathic) arthritis under treatment with dis-ease modifying antirheumatic drugs (DMARDs).Methods: Data regarding enteropathic arthritis (EA) were collected fromthe TReasure database, a nation-wide multicenter observational registry ofinflammatory arthritis patients.Results: Among 4066 patients with seronegative spondyloarthropaties(SpA), 156 (3.8%) had EA, not reflecting a true prevalence due to selec-tion bias. Demographic and clinical features according to IBD groupswere summarized in Table 1. Rates of presence of sacroiliitis were simi-lar between patients with UC and CD (39.9% and 60.1%, p=0.086respectively). Rates of HLA-B27 positivity were 31.6% and 7.1% inpatients with and without radiographic sacroiliitis, respectively (p=0.101).Enthesitis, dactylitis, psoriasis, family history forSpA, ESR, CRP, BASDAIand ASDAS levels had similar distributions in patients with and withoutradiographic sacroiliitis. Rates of “never-smoked” (26.5% vs 64.7%) and“current smoking” (32.4% vs 17.6%) significantly differed in patients withand without sacroiliitis (overall p=0.012)Conclusion: Our data confirm an association between smoking statusand disease manifestations, particularly radiographic sacroiliitis.REFERENCES[1] Fries W. Clinical features and epidemiology of spondyloarthritides associ-ated with inflammatory bowel disease. World J Gastroenterol 2009; 15:2449-2455.Disclosure of Interests: Orhan Küçükşahin: None declared, AbdulsametErden: None declared, Ufuk İlgen: None declared, Sedat Kiraz: Nonedeclared, Ali İhsan Ertenli: None declared, Nazife Sule Yasar Bilge: Nonedeclared, Timuçin Kaşifoğlu: None declared, Ediz Dalkılıç Grant/researchsupport from: MSD and Abbvie, Consultant for: MSD, Abbvie,Roche,UCB, Pfizer and Novartis, Speakers bureau: MSD, Abbvie,Roche, UCB,Pfizer and Novartis, Cemal Bes: None declared, Nilüfer Alpay Kanıtez:None declared, Hakan Emmungil Grant/research support from: MSD,Roche, Pfizer, Abbvie, Consultant for: Novartis, Roche, Speakers bureau:MSD, Roche, Pfizer, Abbvie,Celltrion, Novartis, Pamir Atagündüz: Nonedeclared, Belkis Nihan Seniz: None declared, Burcu Yağız: Nonedeclared, Süleyman Serdar Koca: None declared, Muhammet Çınar: Nonedeclared, Aşkın Ateş: None declared, Servet Akar Grant/research supportfrom: MSD, Abbvie, Roche, UCB, Novartis, Pfizer, Amgen, Consultant for:MSD, Abbvie, Roche, UCB, Novartis, Pfizer, Amgen, Speakers bureau:Pfizer, Önay Gerçik: None declared, Duygu Ersözlü: None declared, Veliyazısız: None declared, Gezmiş Kimyon: None declared, Müge Aydın:None declared, Rıdvan Mercan: None declared, Burak Öz: Nonedeclared, Zeynel Abidin Akar: None declared, Omer Karadag: None1824 Scientific Abstracts on July 30, 2022 by guest. Protected by copyright.http://ard.bmj.com/Ann Rheum Dis: first published as 10.1136/annrheumdis-2019-eular.5888 on 27 May 2019. Downloaded from declared, Bahar Keleşoğlu: None declared, Sedat Yılmaz: None declared,Yavuz Pehlivan: None declared, Ender Terzioğlu: None declared, LeventKılıç: None declared, Sukran Erten: None declared, Koray Taşçılar: Nonedeclared, Umut Kalyoncu Grant/research support from: MSD, Roche,UCB, Novartis and Pfizer, Consultant for: MSD, Abbvie, Roche, UCB,Novartis, Pfizer and Abdi Ibrahim, Speakers bureau: MSD, Abbvie, Roche,UCB, Novartis, Pfizer and Abdi IbrahimDOI: 10.1136/annrheumdis-2019-eular.5888AB0724 DOSE PREGNANCY AND VAGINAL DELIVERY WORSENANKYLOSING SPONDYLITIS?Jung Sun Lee1, Ji Seon Oh1, Wook Jang Seo2, Seokchan Hong1, Yong-Gil Kim1,Chang-Keun Lee1, Bin Yoo1. 1University of Ulsan College of Medicine, AsanMedical Center, Seoul, Korea, Rep. of (South Korea); 2Veterans Health ServiceMedical Center, Seoul, Korea, Rep. of (South Korea)Background Ankylosing spondylitis (AS) affects the sacroiliac joints and com-monly occurs in those at the reproductive age. Women with AS have a higher rateof cesarean section (CS) compared with healthy controls.Objectives This study determined the effect of pregnancy and delivery methodson AS worsening by analyzing prescription pattern.Methods Based on the Korean Health Insurance Review and Assessment Serv-ice claims database, subjects comprised female patients aged 20–49 years withan AS. Alteration of prescriptions was defined by changing the at two time periodsof 1–2 years pre-delivery and 1-year post-delivery. We compared alteration of pre-scriptions between AS patients with delivery and 1:1 matched AS patients withoutdelivery. In addition, among AS patients with delivery, alteration of prescriptionsaccording to delivery method was evaluated.Results Among 6,821 female patients with AS, 996 patients in the delivery groupwere younger, had a higher proportion of non-drug use, and had lower rates ofcomorbidity than the no delivery group. The alteration of prescriptions did not differbetween the AS with delivery and the AS without delivery groups (OR 0.76, 95%CI 0.56–1.05). Furthermore, the overall alteration of prescriptions did not differ sig-nificantly between vaginal delivery (VD) and CS (OR 0.72, 95% CI 0.45–1.14).Conclusion The rate of alteration of prescriptions was comparable between theAS patients with and without delivery. There was no association between VD andalteration of prescriptions compared with CS. Taken together, pregnancy and VDmay not be assumed to be factors of AS worsening.Disclosure of Interests None declaredDOI: 10.1136/annrheumdis-2019-eular.2519AB0725 ASSOCIATION BETWEEN RADIOGRAPHICPROGRESSION AND CARDIOVASCULAR RISK INSPONDYLOARTHRITIS: DATA FROM COSPARREGISTRYLadehesa Pineda Lourdes1, Gómez García Ignacio2, María del Carmen CastroVillegas2, Pedro Seguí Azpilcueta3,Maria del Carmen Abalos-Aguilera4, BautistaAguilar Laura2, Inmaculada Concepcion Aranda-Valera5, Rocio Segura5,RafaelaOrtega Castro5, Clementina López-Medina6, Pérez Sánchez Laura7, PucheLarrubia Maria Ángeles5, Chary Lopez-Pedrera4,Font Ugalde Pilar5, GarridoCastro Juan Luis6, Alejandro Escudero Contreras5, Eduardo Collantes Estevez5,Jiménez Gómez Yolanda4, COSPAR Study Group. 1Universitary Hospital ReinaSofia, Rheumatology, Córdoba, Spain; 2Reina Sofía University Hospital/IMIBIC/University of Cordoba, Rheumatology, Cordoba, Spain; 3Reina Sofía UniversityHospital/IMIBIC/University of Cordoba, Radiology, Córdoba, Spain; 4IMIBIC,Córdoba, Spain; 5Reina Sofía University Hospital/IMIBIC/University of Cordoba,Rheumatology, Córdoba, Spain; 6University of Córdoba, Córdoba, Spain; 7ReinaSofía University Hospital/IMIBIC/University of Cordoba, Rheumaology, Córdoba,SpainBackground: Studies suggest that radiographic damage is associated withcardiovascular (CV) risk in axial spondyloarthritis (axSpA). However, therelationship among disease characteristics directly related to structuraldamage and CV risk has not yet been fully clarified.Objectives: To analyze the association of structural damage with thepresence of atherosclerotic plaques via carotid ultrasound (US) and theincreased CV risk in a registry of patients with SpA.Methods: Eighty-five patients with SpA (ASAS criteria) from the SpAregistry from Cordoba (CoSpaR) were selected for a cross-sectional studyand underwent a complete clinical history, physical examination and bio-chemical analysis. Variables about demographics, clinical parameters andCV risk factors were collected. CV risk was evaluated by estimatingSCORE index and assessing presence of atherosclerotic plaques throughcarotid US performed by a qualified radiologist. Independent-samples ttest was used to evaluate the association between radiologicalcharacteristics and presence of atherosclerosis. Multiple lineal regression(MLR) was performed to assess the variables potentially associated withincreased SCORE. All comparisons were bilateral.Results: Baseline characteristics are shown in the table. Values aremean±SD for quantitative and N (%) for qualitative variables. Regardingcharacteristics related with radiographic damage and CV risk, they exhib-ited a mSASSS of 14.84±18.4 (7.27±9.64 in cervical spine and 7.72±10.14 in lumbar spine). Average BMI 26.88±4.13, 33 (38.8%) weresmokers, 16 (18.8%) had diagnosis of arterial hypertension, 1 (1.2%) ofdiabetes mellitus, 13 (15.3%) of hyperlipidemia, and 8 (9.4%) took lipidlowering drugs. Examination with carotid US found that 14 (16.5%)patients had previously unknown atherosclerotic plaques. After classifica-tion according to SCORE index, 60 (76.9%) had low CV risk, 10 (12.8%)moderate, and both high and very high CV risk categories had 4 (5.1%)patients each.In patients with atherosclerotic plaques, age, disease duration and varia-bles related to radiographic damage (mSASSS [total, cervical and lumbar],and bone bridges) were significantly higher (p<0.05). In addition, mSASSSin cervical spine (p=0.063) and age (p<0.001) were associated with theSCORE and were predictors of increased CV risk in MLR analysis.Age (years) (N=85) 44.5±12.2Sex (males) (N=85) 59 (69.4)HLA B27 (N=83) 71 (83.5)axSpA (N=85) 79 (92.9)Radiographic axSpA (N=77) 63 (74.1)BMI (kg/m2) (N=80) 26,9±4.13Disease duration (years) (N=82) 18.01±13.62Smokers (N=84) 33 (38.8)ASDAS-CRP 3.13±1.05ASAS HI (N=82) 4.05±3.8Conclusion: Presence of atherosclerosis is associated with age, diseaseduration and radiographic damage in SpA. Age and structural damageespecially in the cervical spine predicted a greater CV risk. Thus, it isimportant to identify these patients in order to maintain tight control andavoid development of CV disease.Acknowledgement: Funded by: JA PI-0139-2017Disclosure of Interests: Ladehesa Pineda Lourdes: None declared,Gómez García Ignacio: None declared, María del Carmen Castro Vil-legas Paid instructor for: MSD, Abbvie, Pfizer, Janssen, Lilly, Roche,Pedro Seguí Azpilcueta: None declared, Maria del Carmen Abalos-Aguilera: None declared, Bautista Aguilar Laura: None declared,Inmaculada Concepcion Aranda-Valera: None declared, Rocio Segura:None declared, Rafaela Ortega Castro: None declared, ClementinaLópez-Medina: None declared, Pérez Sánchez Laura: None declared,Puche Larrubia Maria Ángeles: None declared, Chary Lopez-Pedrera:None declared, Font Ugalde Pilar: None declared, Garrido CastroJuan Luis: None declared, Alejandro Escudero Contreras: Nonedeclared, Eduardo Collantes Estevez: None declared, Jiménez GómezYolanda: None declaredDOI: 10.1136/annrheumdis-2019-eular.6050AB0726 WHAT IS THE IMPACT OF MRI ON THE PERFORMANCEOF THE ASAS CLASSIFICATION CRITERIA IN PATIENTSPRESENTING WITH UNDIAGNOSED BACK PAIN?1,2Walter P. Maksymowych, Raj Carmona3, James Yeung4, Jon Chan5,Liam Martin6, Sibel Aydin7, Dianne Mosher6, Ariel Masetto8, Stephanie Keeling1,Olga Ziouzina6, Sherry Rohekar9, Joel Paschke2, Amanda Carapellucci2, RobertG. Lambert1. 1University of Alberta, Edmonton, Canada; 2CaRE Arthritis,Edmonton, Canada; 3McMaster University, Hamilton, Canada; 4James YeungRheumatology, Vancouver, Canada; 5Artus Health Center, Vancouver, Canada;6University of Calgary, Calgary, Canada; 7University of Ottawa, Ottawa, Canada;8University of Sherbrooke, Sherbrooke, Canada; 9Lawson Health ResearchInstitute, London, CanadaBackground: Several cohorts have reported the performance of theASAS classification criteria in settings where clinical, radiographic, andMRI features have been simultaneously incorporated into the diagnosticevaluation in arriving at a gold standard for the testing of the criteria.MRI improves diagnostic precision but access is limited and it is there-fore still important to understand how the criteria perform in a settingwhere diagnostic evaluation can be conducted sequentially before andafter MRI assessment. We hypothesized that the ASAS criteria woulddemonstrate enhanced specificity when MRI is available due to enhanceddiagnostic precision.Scientific Abstracts 1825 on July 30, 2022 by guest. Protected by copyright.http://ard.bmj.com/Ann Rheum Dis: first published as 10.1136/annrheumdis-2019-eular.5888 on 27 May 2019. Downloaded from 

Smoking May Be Related to Sacroiliitis in Enteropathic Arthritis Patients: Treasure Real-Life Preliminary Data

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Smoking May Be Related to Sacroiliitis in Enteropathic Arthritis Patients: Treasure Real-Life Preliminary Data

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