Background: In India, HIV epidemic is in fourth decade and has the heterogeneity. The trend indicated HIV infection spreads from high risk behavior groups to general population. Maternal to foetal HIV transmission rate is found to vary from 20 to 25% in absence of any interventions. Newly infected persons contribute to the total number of persons living with HIV, they will progress to disease and death over the time and are a potential source of further infection. Maternal HIV status directly affects the perinatal transmission and hence the paediatric HIV cases. This transmission of HIV from mother to child can be prevented by appropriate measures. So this study is intended to identify ten years’ trends in HIV seroprevalence among antenatal population at a tertiary hospital in Dhule, Maharashtra, India.Methods: Retrospective study of ICTC evaluation of pregnant women attending antenatal clinic at obstetrics and gynaecology department of Shri Bhausaheb Hire Government Medical College in Dhule, Maharashtra, India. Blood samples were collected after informed consent and pre-test counseling. The samples were tested for HIV antibodies as per WHO and NACO guidelines. The data of ten years period from January 2004 to December 2013 was evaluated to identify the trends of HIV seroprevalence among pregnant women attending antenatal clinic.Results: 309 pregnant women were HIV positive out of 70453 tested from 84608 ANC women during the study period. The overall prevalence for the 10 years was 0.44%. HIV prevalence had reduced from 0.89% in 2004 to 0.17% in 2013. Maximum HIV positive women i.e. 63.2% were 18 to 23 years old, primigravida (53.8%) and from rural area (58.5%). Mother to foetal transmission was noted 10 babies were detected to be HIV positive while 223 were HIV negative. 10 HIV positive mothers decided for MTP, while in 36 neonatal death was noted.Conclusions: Declining HIV seroprevalence rate is noted among pregnant women attending the antenatal clinics from 2004 to 2013. The effective implementation of prevention of parent to child transmission of HIV/AIDS (PPTCT) programmed is helping in control of the spread of HIV
