THE FAT PAT TISSUE EXPRESSES A PATHOGENIC PROFILE OF INFLAMMATORY MEDIATORIES AND 4-HNE IN PATIENTS WITH OSTEOARTHRITIS

Abstract

Introduction: In this study we aimed to estimate if there is a releation between some inflammatory or adipocyte-derived cytokines as IL-1 beta, IL-6, TNF-alfa, VEGF, 4-HNE, macrophages, mast cells and osteoarthirites. Especially 4-HNE which associated obesity is a new marker for estimating the chondral injuries and there is a poor evidence of it's effect on IFP and osteoarthritis