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Coordination Complex Sh2 Domain Proteomimetics: An Alternative Approach To Disrupting Oncogenic Protein-Protein Interactions
Authors
Joel A. Drewry
Steven Fletcher
+3 more
Denys Marushchak
Peibin Yue
Wei Zhao
Publication date
1 January 2010
Publisher
'Information Bulletin on Variable Stars (IBVS)'
Abstract
We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(ii) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity. © The Royal Society of Chemistry 2010
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Last time updated on 18/10/2022