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Fabrication Of Ultrathin Polyelectrolyte Fibers And Their Controlled Release Properties
Authors
Anindarupa Chunder
Sourangsu Sarkar
Yingbo Yu
Lei Zhai
Publication date
1 August 2007
Publisher
'Information Bulletin on Variable Stars (IBVS)'
Abstract
Ultrathin fibers comprising 2-weak polyelectrolytes, poly(acrylic acid) (PAA) and poly(allylamine hydrochloride) (PAH) were fabricated using the electrospinning technique. Methylene blue (MB) was used as a model drug to evaluate the potential application of the fibers for drug delivery. The release of MB was controlled in a nonbuffered medium by changing the pH of the solution. The sustained release of MB in a phosphate buffered saline (PBS) solution was achieved by constructing perfluorosilane networks on the fiber surfaces as capping layers. Temperature controlled release of MB was obtained by depositing temperature sensitive PAA/poly(N-isopropylacrylamide) (PNIPAAM) multilayers onto the fiber surfaces. The controlled release of drugs from electrospun fibers have potential applications as drug carriers in biomedical science. © 2007 Elsevier B.V. All rights reserved
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Last time updated on 18/10/2022