Nine patients with fungal keratitis were treated with systemic fluconazole, which is a second generation triazole compound and has been proven to be an effective antifungal agent in experimental studies. The lesions healed with peroral 200 mg fluconazole per day, in a period of minimum 3, maximum 6 weeks. Neither a complication or any side-effect resulted from this therapy. One eye was eviscerated because of deteriorating infection and panophthalmitis. This is a pilot study investigating the efficacy of systemic fluconazole treatment in fungal keratitis, and we concluded that it is an effective alternative of antifungal treatment
