WOS: 000281800400004Although dioctyl adipate (DOA. C(22)H(42)O(4)) is one of the most common plasticizers that are used for polymerization, the ecotoxicological effects of it is not well known. From this point of view, aim of this preliminary investigation was to analyze the histopathological changes in the liver of Labidochromis caeruleus (yellow princess), exposed to 0.75 ppm DOA for 30 days. When compared to controls, the most prominent changes occurred in the DOA exposed group were noted as a significant steatosis (fat deposisiton), fibrosis and expanding necrotic areas. The dilatation of sinusoids and central veins, poikilocytosis, and hemorrhage were also observed. The data presented in this study shows that. DOA is a hepatotoxic chemical at least for Labidocromis caerulous
