STRIEPEN Boris

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STRIEPEN, Boris

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The Biology of Cryptosporidium Infection著者 STRIEPEN Borisjournal orpublication titleJournal of Integrated Field Sciencevolume 17page range 28-29year 2020-03URL http://hdl.handle.net/10097/0012879528Oral Session 29Keynote LectureS-1. The Biology of Cryptosporidium InfectionBoris STRIEPENDepartment of Pathobiology, School of Veterinary Medicine, University of PennsylvaniaThe protozoan parasite Cryptosporidium is a leading cause of severe diarrhea in young children and an important contributor to early childhood mortality. Effective drugs and vaccines are lacking, in part due to the overall poor tractability of this parasite. To overcome this, we established molecular genetics for Cryptosporidium and a natural mouse model of infection. This seminar will focus on recent and largely unpublished work to understand the cell biology of Cryptosporidium infection. First, I will discuss how the parasite manipulates the host cell by injecting proteins using two independent delivery systems. Then I will describe what we are learning about the parasite’s lifecycle. The entire cycle, including an asexual and a sexual phase unfolds over three days and is tractable in culture and in animals for a significant portion. This is a remarkably simple model that can be interrogated by live cell imaging, single cell sequencing and genetic manipulation.

The Biology of Cryptosporidium Infection

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The Biology of Cryptosporidium Infection

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