FURUKAWA Kyohei

FURUKAWA Mutsumi

HIRAKAWA Ryota

KIKUSATO Motoi

NOCHI Tomonori

NURJANAH Siti

SATO Kan

TOYOMIZU Masaaki

USAMI Katsuki

紀要類（bulletin）Session for Studentsdepartmental bulletin pape

HIRAKAWA, Ryota

KIKUSATO, Motoi

NURJANAH, Siti

FURUKAWA, Kyohei

FURUKAWA, Mutsumi

USAMI, Katsuki

SATO, Kan

TOYOMIZU, Masaaki

NOCHI, Tomonori

Tohoku University Repository (TOUR) / 東北大学機関リポジトリ

The Effects of Heat Stress on the ImmuneFunction and Morphological Structure of AvianGut-associated Lymphoid Tissues著者 HIRAKAWA Ryota, KIKUSATO Motoi, NURJANAH Siti,FURUKAWA Kyohei, FURUKAWA Mutsumi, USAMIKatsuki, SATO Kan, TOYOMIZU Masaaki, NOCHITomonorijournal orpublication titleJournal of Integrated Field Sciencevolume 18page range 39-39year 2021-03URL http://hdl.handle.net/10097/00131392 39Session for StudentsThe Effects of Heat Stress on the Immune Function and Morphological Structure of Avian Gut-associated Lymphoid TissuesRyota HIRAKAWA1,2, Motoi KIKUSATO1,2, Siti NURJANAH1,2, Kyohei FURUKAWA1,2,  Mutsumi FURUKAWA1,2, Katsuki USAMI1,2, Kan SATO1,2, Masaaki TOYOMIZU1,2  and Tomonori NOCHI1,21International Education and Research Center for Food and Agricultural Immunology 2Graduate School of Agricultural Science, Tohoku UniversityHigh ambient temperature increases susceptibility to infections caused by enteric pathogens, such as Salmonella spp. in broiler chickens. Among numerous factors involved in immune activation and regulation, secretory immunoglobulin (Ig), especially IgA, has been known to play a key role in the gastrointestinal tract in protecting the tissues from pathogen-medicated functional disorder. However, knowledge of the effect of heat stress (HS) on the gastrointestinal Ig production in chickens remains obscures. This study investigated the immune function and morphological structure of cecal tonsils and cecal patches, both of which are composed of lymphoid follicles, in broiler chickens reared under either thermoneutral (24.5°C) or HS conditions (34.5°C). Our results revealed that both cecal tonsils and cecal patches displayed severe depression of Bu1+ B cells and CD3+ T cells including CD4+ T cells and CD8+ T cells in the HS conditions. HS also caused a hypoplasia of germinal centers in cecal tonsils, wherein mature B cells differentiate into plasmablasts undergoing Ig class-switching. In contrast, such morphological structure necessary for B cell differentiation was maintained adequately in the cecal patches even under the HS conditions. Due to the resistance of cecal patches to HS, the production of IgM, IgA and IgY in the gastrointestinal tract of heat-stressed chickens was sufficiently sustained at same level as those of thermoneutral chickens. These findings suggested that the breeding and/or feeding strategy to preserve the immune function and morphological structure of cecal patches may be useful to maintain the health of chickens in the HS conditions.

The Effects of Heat Stress on the Immune Function and Morphological Structure of Avian Gut-associated Lymphoid Tissues

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The Effects of Heat Stress on the Immune Function and Morphological Structure of Avian Gut-associated Lymphoid Tissues

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