In the present mini review, we describe 1) a new screening system for selecting probiotic strains from lactic acid bacteria (LAB), mainly Lactobacillus acidophilus group bacteria, with strong adhesion to the human intestinal tract, 2) characteristics of immunostimulative oligo DNA motifs in LAB (L. gasseri) strains and a new evaluation system with a transfectant expressing porcine Toll-1ike receptor 9 for selection of immunostimulative LABs, and 3) characteristics of antimicrobial peptides (bacteriocins), especially gasericin A from L. gasseri LA39. In the future, it is expected that superior functional foods containing more effective probiotic LAB will be developed by the use of our proposed mass screening system
