Siddha system of medicines is known for its herbal in origin. Herbal plays a major role in treating acute and chronic diseases. Cardiovascular diseases (CVDs) is the life-threatening disease that contributes a leading cause of death day by day across the world. A change in lifestyle modification is the one of the risks of CVDs. This review paper attempts to facilitate the cardioprotective activity by providing different types of medicinal plants and its botanical distribution, description, chemical constituents and pharmacological activity. Few important herbs will protect the human being from CVDs and gives health and quality of life. In this paper, the authors explores the effect of cardioprotective activity in medicinal plants as follows, Terminalia chebula (Kadukkai), Piper longum (Thippili), Zingiber officinale (Inji), Tinospora cordifolia (Seenthil), Asparagus racemosus (Thanneervitan), Embelia ribes
(Vaaivilangam), Andrographis paniculata (Nilavembu), Nelumbo nucifera (Thaamarai), Allium sativum (Vellaipoondu), Bauhinia variegata (Mantharai)
