WPŁYW FENOFIBRATU NA AKTYWNOŚĆ OSOCZOWEJ PARAOXONAZY I WSKAŹNIKÓW ZAPALNYCH U CHORYCH Z HIPERLIPIDEMIĄ MIESZANĄ

Abstract

Background: Lipid lowering therapy with statins is beneficial because of improvement in lipoprotein concentrations and additional pleiotropic effects. However, less is known about the pleotropic effect of fibrates.Aim: To investigate the effects of fenofibrate therapy on inflammatory markers and serum paraoxonase activity in patients with combined hyperlipidemia in addition to their lipid lowering effects.Methods: Fifty patients (18 women, 32 men, mean age 50±8.7 years) with a history of combined hyperlipidemia and coronary artery disease were enrolled into the study. Serum lipids, inflammatory markers (high sensitivity C-reactive protein (hs-CRP) and fibrinogen levels) and paraoxonase levels were determined before and after two months of 250 mg per day of fenofibrate treatment.Results: Fenofibrate decreased plasma fibrinogen level by 41% (from 3.9±0.9 mg/dl to 2.3±0.48 mg/dl,