Given the high density of urban spaces, residents and tourists share resources and infrastructure in limited spaces. The purpose of the study is to investigate the influence of residents’ perceived tourism impacts on their attitudes towards tourism growth, the effect of proximity to tourism center on residents’ attitudes, and how this effect is moderated by residents’ demographic features (age, gender, length of residence) in urban settings. A total of 251 responses were collected in downtown Greenville, a tourist zone located in the heart of Greenville, SC, USA. Using multiple regression models and ANOVA, the study suggested that (1) economic impact was the most important predictor of residents’ attitudes towards tourism growth, (2) downtown residents were more favorable of tourism growth than county residents, and (3) Age and gender moderated the effect of proximity to a tourism center on residents’ attitudes towards tourism growth