Histopathological Pancreas Analysis of Hylocereus polyrhizus Peel Ethanolic Extract on Alloxan Induced Diabetic Mice

Abstract

Diabetes is a metabolic disorder due to the disruption of the pancreas in producing insulin. Alloxan is a compound that has diabetogenic properties and is toxic, especially to pancreatic beta cells. When given to experimental animals, namely mice, it will cause them to become diabetic. Mice were separated into five groups consisting of 6 mice. Mice were divided into a normal control group without alloxan, a diabetic control group with alloxan, an extract treatment group of 100 mg/kg and 300mg/kg Hylocereus polyrhizus peel extract, and a positive control group with 600 μg/kg Glibenclamide. All treatments were given orally for 14 days. Neck dislocations were performed on all groups of mice on the 14th day after extract administration to retrieve pancreatic tissue. In this study, dragon fruit peel extract improved pancreatic beta cell damage compared to the diabetes control group. Giving ethanol extract of red dragon fruit peel (H. polyrhizus) can improve the histopathology of the pancreas in mice with diabetes mellitus. Ethanol extract of red dragon fruit peel (H. polyrhizus) at a dose of 300 mg/kg BW is the optimum dose for repairing pancreatic beta cell damage in mice with diabetes mellitus. Keywords: Alloxan, Diabetes, Histopathological pancreas, Hylocereus polyrhizus peel extract, Mic