In the current social background of frequent epidemics, shopping centers, as commercial buildings with a large number of people, it is very important to reduce the risk of environmental infection. This paper takes the Weilaishi Shopping Center in Handan as an example, summarizes the epidemic prevention status of five types of spatial nodes through field investigation, and analyzes the shortcomings of the existing emergency design of the Weilaishi Shopping Center. Based on the analysis results, this paper puts forward the optimization strategy from the spatial level, which provides a certain reference value for the research on the improvement of shopping center space environment emergency capability