Emami, M.

Khorshidi, M.

Moradi Moghaddam, O.

Olang, B.

Zarezadeh, M.

eprints Iran University of Medical Sciences

Promising impacts of mesenchymal stem cell therapy in treatment ofSARS-CoV-2 (COVID-19)Masoud Khorshidi, Ph.D.a,b, Meysam Zarezadeh, Ph.D.c,d,**, Mohammadreza Emami, M.Sc.e,Beheshteh Olang, MD, Ph.Db, Omid Moradi Moghaddam, MD, FCCMf,*a Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iranb Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research Institute for Children’s Health, Shahid Beheshti University of Medical Sciences,Tehran, Iranc Department of Clinical Nutrition, Nutrition Research Center, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Irand Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IraneDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iranf Trauma and Injury Research Center, Critical Care Medicine Department, Iran University of Medical Sciences, Tehran, IranA R T I C L E I N F OArticle History:Received 11 August 2020Accepted 17 August 2020Available online 19 August 2020To the EditorA novel coronavirus named COVID-19 has begun to spread inWuhan, China from December 2019 and become a global health con-cern.1 Individuals with underlying diseases are at greater risk andmore prone to be critically ill in case of infection so that mortalityrate is 49% in subjects entering intensive care units.2 It has beenreported that critically ill COVID-19 patients remarkably have ele-vated levels of pro-inflammatory cytokines including IL-6, G-CSF,IP10, MCP1, MIP1A, and TNFa, contributing to outbreak of cytokinestorm.3 These turn of events lead to acute respiratory distress syn-drome and ultimately maybe death2 and glucocorticoids were notefficient in reducing rate of mortality.4It has been suggested that mesenchymal stem cell (MSC) trans-plantation could be considered as a beneficial approach in treatmentmany disease. MSC exerts its positive impacts through immunomo-dulation and differentiation stimulation.5 It has proposed that patho-gen molecules such as double-stranded RNA in virus is able toincrease induction of toll-like receptors (TLRs) on MSC resulting inmanifestation of immunomodulatory effects of MSC.6 Darwish et al.demonstrated that MSC is potentially able to treat H5N1 infectionwhich has a cytokine profile similar to COVID-19.7 The mechanismsof action of MSC on COVID-19 treatment schematically are shown onFig. 1.Therefore, MSC therapy potentially could be considered as an effi-cacious and safe treatment approach in COVID-19-induced pneumo-nia. In this regard, Leng et al. recently demonstrated that withperfusion of 1 £ 106 cells per kilogram of weight, almost all the clini-cal symptoms such as fever, breath shortness, and low oxygen satura-tion disappeared and the inflammation levels were relieved 2-4 daysafter MSC transplantation.8 Moreover, in a critically ill 65 years oldwoman, MSC transplantation with 5 £ 107 cells three times resultedin significant decrease in CRP and increase in CD3+, CD4+ and CD8+ Tcells to the normal ranges. Also, CT images implied to remarkablerelieve in pneumonia.9 Furthermore, there are 30 registered studiesinvestigating MSC therapy on COVID-19 to explore whether MSCtransplantation could be able to shed the light in COVID-19 treat-ment. A summary of characteristics of registered studies are pre-sented in Table 1.Author contributionMasoud Khorshidi: Conceptualiation, Investigation, Methodology,Software, Visualization; Meysam Zarezadeh: Data curation, Investiga-tion, Validation, Visualization, Writing - original draft, Writing -review and editing; Mohammadreza Emami: Data curation, Visuali-zation; Beheshteh Olang: Data curation, Visualization, Validation;Omid Moradi Moghaddam: Conceptualization, Project administra-tion, Supervision, Visualization.* Corresponding author at: Trauma and Injury Research Center, Critical Care Medi-cine Department, Iran University of Medical Sciences, Shahid Hemmat Highway, Teh-ran, Iran.** Corresponding author at: Ph.D. of Nutritional Sciences, School of Nutrition andFood Sciences, Tabriz University of Medical Sciences, Attar-Neishaburi St., GolgashtAlley, Azadi Blvd., Tabriz, Iran.E-mail addresses: zarezadehm@tbzmed.ac.ir (M. Zarezadeh),moradimoghadam@yahoo.com (O.M. Moghaddam).https://doi.org/10.1016/j.hrtlng.2020.08.0070147-9563/© 2020 Elsevier Inc. All rights reserved.Heart & Lung 49 (2020) 745748Contents lists available at ScienceDirectHeart & Lungjournal homepage: www.heartandlung.com

Promising impacts of mesenchymal stem cell therapy in treatment of SARS-CoV-2 (COVID-19)

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Promising impacts of mesenchymal stem cell therapy in treatment of SARS-CoV-2 (COVID-19)

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